Verkazia is specifically designed to meet the needs of patients with vernal keratoconjunctivitis (VKC)1-3

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Verkazia is designed for kids with VKC

Verkazia’s cationic vehicle delivered ~4x more cyclosporine to the cornea compared to a commercially available cyclosporine solution 0.05%.4

*In an ex-vivo porcine penetration study utilizing 50uL4

 
Verkazia is formulated with a unique cationic ophthalmic emulsion

Cationic ophthalmic emulsion formulation delivers cyclosporine to target tissues in the cornea and conjunctiva to inhibit chronic inflammation in VKC3

Cyclosporine is embedded in positively-charged (cationic) nanosized droplets3

Cationic droplets form electrostatic attraction with the negatively-charged (anionic) ocular surface3

  • Enables rapid spread across cornea3
  • Prolongs and increases surface contact compared with anionic and unpolarized agents3

Cationic ophthalmic emulsion alleviates discomfort by reducing inflammation.

Cyclosporine embedded in nanodroplets

Cationic ophthalmic emulsion formulation delivers cyclosporine to target tissues in the cornea and conjunctiva to inhibit chronic inflammation in VKC3

Nanodroplets are positively charged

Cationic ophthalmic emulsion formulation delivers cyclosporine to target tissues in the cornea and conjunctiva to inhibit chronic inflammation in VKC3

Cyclosporine is embedded in positively-charged (cationic) nanosized droplets3
 

Nanodroplets form an electrostatic attraction with anionic ocular surface

Cationic ophthalmic emulsion formulation delivers cyclosporine to target tissues in the cornea and conjunctiva to inhibit chronic inflammation in VKC3

Cationic droplets form electrostatic attraction with the negatively-charged (anionic) ocular surface3

Attraction helps nearly double concentration of cyclosporine in the eye

Cationic ophthalmic emulsion formulation delivers cyclosporine to target tissues in the cornea and conjunctiva to inhibit chronic inflammation in VKC3

  • Enables rapid spread across cornea3
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Cationic ophthalmic emulsion formulation delivers cyclosporine to target tissues in the cornea and conjunctiva to inhibit chronic inflammation in VKC3

  • Prolongs and increases surface contact compared with anionic and unpolarized agents3

VKC is a complex and chronic disease that may pose serious risks to the eye

VKC affects young boys

average age of onset of VKC, typically in boys, primarily affected by chronic bilateral ocular inflammation, which can persist into adolescence and adulthood2,5

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Symptoms can occur year-round
Therea are about 49,000 cases of VKC in the United States

of VKC diagnosed in the United States in 20176

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Young girls can be affected by VKC too
25% of cases have corneal involvement

of VKC cases involve the cornea, making them severe enough to be sight-threatening2

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VKC can prevent kids from enjoying daily activities
50% of cases have no specific allergenic cause

of VKC patients do not have a clear allergenic trigger. Genetic, hormonal, and nonspecific environmental factors play a role, too7

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Patients may have unpredictable recurrences

 

VKC can be hard to identify. Learn the hallmark signs and symptoms

In addition to common allergic conjunctivitis symptoms like redness, tearing, mucous discharge, and itching, look for any of these hallmarks of VKC7,8:

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    Photophobia7,8

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    Horner-Trantas dots7,8
    Focal white limbal dots

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    Shield ulcers7,8

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    Upper tarsal giant (“cobblestone”) papillae7,8
    >1 mm in diameter with flattened tops

VKC can be differentiated from AKC by its earlier age of onset and pattern of involvement on the upper tarsal conjunctiva8

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Prolonged or frequent use of corticosteroids is a real concern for patients with unpredictable symptoms throughout the year

Up to 28% of VKC patients

have an adverse response to chronic steroid use, such as elevated IOP, which can progress to complications such as glaucoma in 2% to 5% of cases9

Risks of steroid overuse:

  • Steroid overexposure can cause cataracts

     Cataracts2,10

  • Steroid overexposure can cause glaucoma

    Glaucoma2,10

  • Steroid overexposure can lead to infection

    Infection2,10

  • Steroid overexposure can lead to delayed wound healing

    Delayed wound healing10

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